I've been saying this to a lot of people lately, that Vista (More specifically the Windows Presentation Foundation technology being released at the same time as part of .Net 3.0 which comes on Vista, but can be installed on WinXP systems as well). There is a great opportunity for developers, designers, and develosigners to create new applications like we have never seen before, creating user interfaces, or more specifically user experiences that make more sense for the application than the structured GUI's we've been accustomed to.
Loren shows a great example of this in a project of his that incorporates WPF and Tablet PC technologies.
"with the release of Windows Presentation Foundation (WPF), the time is right. The technologies it provides are a great match for what we're trying to accomplish and they provide a wonderful experience for the user/reader."